| 英文名 |
[methionine synthase] reductase |
| Example Structure |
![Example Structure of [methionine synthase] reductase EC#: 1.16.1.8](/wp-content/uploads/enzyme-structure/1.16.1.8.jpg) |
| 别名 |
EC 2.1.1.135, Methionine synthase cob(II)alamin reductase (methylating), Methionine synthase reductase, MSR, MTRR, NADPH-dependent diflavin oxidoreductase, Reductase, methionine synthase |
| EC Number |
1.16.1.8 |
| CAS编号 |
207004-87-3 |
| Comments |
In humans, the enzyme is a flavoprotein containing FAD and FMN. The substrate of the enzyme is the inactivated cobalt(II) form of EC 2.1.1.13, methionine synthase. Electrons are transferred from NADPH to FAD to FMN. Defects in this enzyme lead to hereditary hyperhomocysteinemia. |
| Cofactor |
FMN;FAD |
| History |
|
| Reactions |
2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP(+) = 2 [methionine synthase]-cob(II)alamin + Nadph + 2 S-adenosyl-L- methionine. |
