| 英文名 |
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase |
| Example Structure |
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| 别名 |
B-cell RAG associated protein, BRAG, GalNAc 4-sulfate 6-O-sulfotransferase, GalNAc(4S)-6-O-sulfotransferase, GalNAc4S 6-O-sulfotransferase, GalNAc4S-6ST, GALNAC4S-6ST/BRAG, GalNAc4S6ST, mGalNAc4S-6ST, N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase |
| EC Number |
2.8.2.33 |
| CAS编号 |
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| Comments |
The enzyme is activated by divalent cations and reduced glutathione. The enzyme from human transfers sulfate to position 6 of both internal residues and non-reducing terminal GalNAc 4-sulfate residues of chondroitin sulfate. Oligosaccharides derived from chondroitin sulfate also serve as acceptors but chondroitin sulfate E, keratan sulfate and heparan sulfate do not. Differs from EC?2.8.2.17, chondroitin 6-sulfotransferase, in being able to use both chondroitin and dermatan as effective substrates. |
| Cofactor |
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| History |
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| Reactions |
(1) 3-phospho-5-adenylyl sulfate + [dermatan]-4-O-sulfo-N- acetylgalactosamine = adenosine 3′,5′-bisphosphate + [dermatan]-4,6-di-O- sulfo-N-acetyl-D-galactosamine. (2) 3-phospho-5-adenylyl sulfate + [chondroitin]-4-O-sulfo-N- acetylgalactosamine = adenosine 3′,5′-bisphosphate + [chondroitin]-4,6- di-O-sulfo-N-acetyl-D-galactosamine. |
