| 英文名 |
N-succinylornithine carbamoyltransferase |
| Example Structure |
 |
| 别名 |
ArgF, N-succinyl-L-ornithine transcarbamylase, SOTCase, succinylornithine transcarbamylase |
| EC Number |
2.1.3.11 |
| CAS编号 |
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| Comments |
This enzyme is specific for N-succinyl-L-ornithine and cannot use either L-ornithine (see EC 2.1.3.3, ornithine carbamoyltransferase) or N-acetyl-L-ornithine (see EC 2.1.3.9, N-acetylornithine carbamoyltransferase) as substrate. However, a single amino-acid substitution (Pro90 ¡ú Glu90) is sufficient to switch the enzyme to one that uses N-acetyl-L-ornithine as substrate. It is essential for de novo arginine biosynthesis in the obligate anaerobe Bacteroides fragilis, suggesting that this organism uses an alternative pathway for synthesizing arginine. |
| Cofactor |
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| History |
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| Reactions |
Carbamoyl phosphate + N(2)-succinyl-L-ornithine = phosphate + N-succinyl- L-citrulline. |
