| 英文名 |
N-terminal methionine Nalpha-acetyltransferase NatB |
| Example Structure |
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| 别名 |
CRA-1, N-acetyltransferase 3, NAA20, NAA25, Naa50p, NAT3, NAT5/SAN, NatB N-alpha-terminal acetylation complex, TCU2 |
| EC Number |
2.3.1.254 |
| CAS编号 |
83452-29-3 |
| Comments |
N-terminal acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free ¦Á-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic, and may also play a role in membrane targeting and gene silencing. The NatB complex is found in all eukaryotic organisms, and specifically targets N-terminal L-methionine residues attached to Asn, Asp, Gln, or Glu residues at the second position. Formerly EC 2.3.1.88. |
| Cofactor |
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| History |
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| Reactions |
(1) Acetyl-CoA + an N-terminal L-methionyl-L-asparaginyl-[protein] = an N-terminal N(alpha)-acetyl-L-methionyl-L-asparginyl-[protein] + CoA. (2) Acetyl-CoA + an N-terminal L-methionyl-L-glutaminyl-[protein] = an N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein] + CoA. (3) Acetyl-CoA + an N-terminal L-methionyl-L-aspartyl-[protein] = an N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] + CoA. (4) Acetyl-CoA + an N-terminal L-methionyl-L-glutamyl-[protein] = an N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] + CoA. |
