N-terminal methionine Nalpha-acetyltransferase NatC EC#: 2.3.1.256; 凯望编码 (ChemWhat Code): 1377089

英文名 N-terminal methionine Nalpha-acetyltransferase NatC
Example Structure Example Structure of N-terminal methionine Nalpha-acetyltransferase NatC EC#: 2.3.1.256
别名 EGAP, embryonic growth-associated protein, MAK10, MAK3, MAK31, Mak31p, Mak3p, N-alpha acetyltransferase 30, N-terminal acetyltransferase complex C, NAA30, NAA35, NAA38, Nalpha-terminal acetyltransferase complex C, NatC, PAM21, protein methionine N-acetyltransferase
EC Number 2.3.1.256
CAS编号
Comments N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free ¦Á-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic, and may also play a role in membrane targeting and gene silencing. The NatC complex is found in all eukaryotic organisms, and specifically targets N-terminal L-methionine residues attached to bulky hydrophobic residues at the second position, including Leu, Ile, Phe, Trp, and Tyr residues. Formerly EC 2.3.1.88.
Cofactor
History
Reactions (1) Acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA. (2) Acetyl-CoA + an N-terminal-L-methionyl-L-isoleucyl-[protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA. (3) Acetyl-CoA + an N-terminal-L-methionyl-L-phenylalanyl-[protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA. (4) Acetyl-CoA + an N-terminal-L-methionyl-L-tryptophyl-[protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA. (5) Acetyl-CoA + an N-terminal-L-methionyl-L-tyrosinyl-[protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-L-tyrosinyl-[protein] + CoA.

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