| 英文名 |
N2-citryl-N6-acetyl-N6-hydroxylysine synthase |
| Example Structure |
 |
| 别名 |
aerD, iuacA, iucA, Nalpha-citryl-Nepsilon-acetyl-Nepsilon-hydroxylysine synthase |
| EC Number |
6.3.2.38 |
| CAS编号 |
|
| Comments |
Requires Mg2+. The enzyme is involved in the biosynthesis of aerobactin, a dihydroxamate siderophore. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme is believed to form an adenylate intermediate prior to ligation. Formerly EC?6.3.2.27. |
| Cofactor |
Mg2+ |
| History |
|
| Reactions |
2 Atp + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine + H(2)O = 2 adp + 2 phosphate + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine. |
