NAD+-protein-arginine ADP-ribosyltransferase EC#: 2.4.2.31; 凯望编码 (ChemWhat Code): 1377779

英文名 NAD+-protein-arginine ADP-ribosyltransferase
Example Structure Example Structure of NAD+-protein-arginine ADP-ribosyltransferase EC#: 2.4.2.31
别名 (adenosine diphosphoribose)transferase, nicotinamide adenine dinucleotide-arginine, actin-specific ADP-ribosyltransferase, ADP-ribosyl-acceptor hydrolase 1, ADP-ribosyltransferase, ADP-ribosyltransferase enzymatic component, ADP-ribosyltransferase-2, ADPRT, alloantigen Rt6.1 , alloantigen Rt6.2 , ALT, arginine ADP-ribosyltransferase 1, arginine specific ADP-ribosyltransferase, arginine specific mono-ADP-ribosyltransferase, arginine-specific adenosine diphosphate ribosyltransferase 1, arginine-specific ADP-ribosyltransferase, arginine-specific ADP-ribosyltransferase 1, arginine-specific ADP-ribosytransferases 1, arginine-specific mono-ADP-ribosyltransferase, arginine-specific mono-ADP-ribosyltransferase A, ARH1, ART, ART1, ART2, ART3, ART4, ART5, Art7.1, Art7.2, ARTase, ARTC1, ARTD15, ARTD15/PARP16, asparagine-specific ADP-ribosyltransferase, AT1 , AT2 , binary toxin, binary toxin A, binary toxin component Ia, C2 toxin, C2I, cARTC2.1, CD196 ADP-ribosyltransferase, CDT, CdtA, cholera toxin, cholix toxin, Dombrock blood group carrier molecule , exoenzyme C3, glycosylphosphatidylinositol-anchored arginine-specific ADP-ribosyltransferase7.1, i-toxin, iota toxin, MART-A, mono(ADP-ribosyl)transferase , mono-ADP-ribosyl-arginine hydrolase, mono-ADP-ribosyltransferase, mono-ADP-ribosyltransferase A, NAD(P)+-arginine ADP-ribosyltransferase, NAD+:arginine ADP-ribosyltransferase, NAD+:arginine ecto-mono(ADP-ribosyl)transferase, NAD+:L-arginine ADP-D-ribosyltransferase, NAD-arginine ADP-ribosyltransferase, NAD-arginine mono-ADP-ribosyltransferase B, NAD-dependent ADPribosyltransferase, NAD:arginine ADP-ribosyltransferase, NAD:arginine ADP-ribosyltransferase B, NarE, PARP16/ARTD15, RT6, RT6.1, RT6.2, T-cell surface protein Rt6.1 , T-cell surface protein Rt6.2 , TcdB2-TccC3, VIP2, Vis toxin
EC Number 2.4.2.31
CAS编号 81457-93-4
Comments Protein mono-ADP-ribosylation is a reversible post-translational modification that plays a role in the regulation of cellular activities [4]. Arginine residues in proteins act as acceptors. Free arginine, agmatine [(4-aminobutyl)guanidine], arginine methyl ester and guanidine can also do so. The enzyme from some, but not all, species can also use NADP+ as acceptor (giving rise to N¦Ø-[(2′-phospho-ADP)-D-ribosyl]-protein-L-arginine as the product), but more slowly [1,5]. The enzyme catalyses the NAD+-dependent activation of EC 4.6.1.1, adenylate cyclase. Some bacterial enterotoxins possess similar enzymatic activities. (cf. EC 2.4.2.36 NAD+¡ªdiphthamide ADP-ribosyltransferase).
Cofactor
History
Reactions NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)- protein-L-arginine.

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