NAD(P)H oxidase (H2O2-forming) EC#: 1.6.3.1; 凯望编码 (ChemWhat Code): 1374519
| 英文名 | NAD(P)H oxidase (H2O2-forming) |
| Example Structure |  |
| 别名 | Atrbohc, AtrbohD NADPH oxidase, AtrbohF NADPH oxidase, BLI-3, dual oxidase, Duox, Duox-DuoxA NADPH oxidase, Duox1, Duox2, gp91phox, gp91phox/Nox2, KOD1, large NOX, LNOX, NAD(P)H oxidase, NAD(P)H oxidase 4, NADH oxidase, NADPH oxidase, NADPH oxidase 1, NADPH oxidase 2, NADPH oxidase 4, NADPH oxidase 5, NADPH oxidase type 4, NADPH-oxidase, NADPHox, NAPDH oxidase, NOX, NOX1, Nox2, NOX3, Nox4, NOX4-art, NOX5, p138 thyroid-oxidase, p138tox, p47phox, p67phox, phagocyte NADPH oxidase, phox, RBOH, RBOHB, RbohF, RDH2, RdxA, renal oxidase, renox, Respiratory Burst Oxidase Homolog, rth5, SsNOX38, superoxide-generating NADPH oxidase, ThOX, ThOX2, thyroid NADPH oxidase, thyroid oxidase, thyroid oxidase 2, TK0304, TK0828, TK1186, TK1299, TK1481 |
| EC Number | 1.6.3.1 |
| CAS编号 | 77106-92-4 |
| Comments | Requires FAD, heme and calcium. When calcium is present, this transmembrane glycoprotein generates H2O2 by transfering electrons from intracellular NAD(P)H to extracellular molecular oxygen. The electron bridge within the enzyme contains one molecule of FAD and probably two heme groups. This flavoprotein is expressed at the apical membrane of thyrocytes, and provides H2O2 for the thyroid peroxidase-catalysed biosynthesis of thyroid hormones. |
| Cofactor | heme;FAD;Ca2+ |
| History | |
| Reactions | NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2). |
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