| 英文名 |
narbonolide synthase |
| Example Structure |
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| 别名 |
methymycin/picromycin polyketide synthase, picromycin/methymycin PKS, picromycin/methymycin polyketide synthase, PICS, PikAI, PikAIII, PikAIV, pikromycin PKS, pikromycin polyketide synthase, type I polyketide synthase PikAIV |
| EC Number |
2.3.1.240 |
| CAS编号 |
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| Comments |
The product, narbonolide, contains a 14-membered ring and is an intermediate in the biosynthesis of narbonomycin and pikromycin in the bacterium Streptomyces venezuelae. The enzyme also produces 10-deoxymethynolide (see EC 2.3.1.239, 10-deoxymethynolide synthase). The enzyme has 29 active sites arranged in four polypeptides (pikAI – pikAIV) with a loading domain, six extension modules and a terminal thioesterase domain. Each extension module contains a ketosynthase (KS), keto reductase (KR), an acyltransferase (AT) and an acyl-carrier protein (ACP). Not all active sites are used in the biosynthesis. |
| Cofactor |
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| History |
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| Reactions |
Malonyl-CoA + 6 (2S)-methylmalonyl-CoA + 5 Nadph = narbonolide + 7 CoA + 7 CO(2) + 5 NADP(+) + 2 H(2)O. |
