| 英文名 |
O-phospho-L-serine-tRNA ligase |
| Example Structure |
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| 别名 |
CysRS, Cysteinyl-tRNA synthetase, More, O-phosphoseryl-tRNA synthetase, phosphoseryl-tRNA synthetase, phosphoseryl-tRNA synthetases, SepRS, sepS |
| EC Number |
6.1.1.27 |
| CAS编号 |
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| Comments |
In organisms like?Archaeoglobus fulgidus?lacking EC?6.1.1.16?(cysteine¡ªtRNA ligase) for the direct Cys-tRNACys?formation, Cys-tRNACys?is produced by an indirect pathway, in which EC?6.1.1.27?ligates?O-phosphoserine to tRNACys, and EC?2.5.1.73?(O-phospho-L-seryl-tRNA: Cys-tRNA synthase) converts the produced?O-phospho-L-seryl-tRNACys?to Cys-tRNACys. The SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism [1].?Methanosarcina mazei?can use both pathways, the direct route using EC?6.1.1.16?(cysteine¡ªtRNA ligase) and the indirect pathway with EC?6.1.1.27?and EC?2.5.1.73?(O-phospho-L-seryl-tRNA: Cys-tRNA synthase) [2]. |
| Cofactor |
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| History |
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| Reactions |
Atp + O-phospho-L-serine + tRNA(Cys) = amp + diphosphate + O-phospho-L- seryl-tRNA(Cys). |
