| 英文名 |
Peptidyl-dipeptidase B |
| Example Structure |
 |
| 别名 |
Atrial di-(tri-)peptidyl carboxyhydrolase, Atrial dipeptidyl carboxyhydrolase, Atrial peptide convertase, Atriopeptin convertase, Dipeptidase, peptidyl-, B, Dipeptidyl carboxyhydrolase |
| EC Number |
3.4.15.4 |
| CAS编号 |
147014-93-5 |
| Comments |
A membrane-bound, zinc metallopeptidase located in mammalian atrial, but not ventricular, myocytes. Although it is capable of converting the 126-residue atriopeptin III directly to atriopeptin I by releasing a C-terminal tripeptide Phe-Arg-Tyr, it is generally restricted to the release of dipeptides. In contrast to peptidyl-dipeptidase A (EC?3.4.15.1) it displays no Cl-?dependence and shows no action on angiotensin I. Conversely, peptidyl-dipeptidase A is unable to release Phe-Arg from the C-terminus of atriopeptin II. |
| Cofactor |
Zn2+ |
| History |
|
| Reactions |
Release of a C-terminal dipeptide or exceptionally a tripeptide. |
