peptidyl-glutamate 4-carboxylase EC#: 4.1.1.90 • ChemWhat中文网

peptidyl-glutamate 4-carboxylase EC#: 4.1.1.90; 凯望编码 (ChemWhat Code): 1381999


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英文名	peptidyl-glutamate 4-carboxylase
Example Structure
别名	carboxylase, Ci-GGC, gamma glutamyl carboxylase, gamma-carboxylase, gamma-glutamyl carboxylase, GGCX, glutamate carboxylase, matrix gamma-carboxyglutamate protein, matrix Gla protein, peptidyl-glutamate 4-carboxylase, peptidyl-glutamate 4-carboxylase (2-methyl-3-phytyl-1,4-naphthoquinone-epoxidizing), two-chain carboxylase, vitamin K carboxylase, vitamin K-dependent carboxylase, vitamin K-dependent gamma-glutamyl carboxylase, vitamin K-dependent gamma-glutamylcarboxylase, VKC, VKD carboxylase
EC Number	4.1.1.90
CAS编号
Comments	The enzyme can use various vitamin-K derivatives, including menaquinol, but does not contain iron. The mechanism appears to involve the generation of a strong base by oxygenation of vitamin K. It catalyses the post-translational carboxylation of glutamate residues of several proteins of the blood-clotting system. 9-12 glutamate residues are converted to 4-carboxyglutamate (Gla) in a specific domain of the target protein. The 4-pro-S?hydrogen of the glutamate residue is removed [5] and there is an inversion of stereochemistry at this position [6].
Cofactor
History
Reactions	[Peptidyl]-4-carboxyglutamate + 2,3-epoxyphylloquinone + H(2)O = [peptidyl]-glutamate + CO(2) + O(2) + phylloquinol.