| 英文名 |
pestivirus NS3 polyprotein peptidase |
| Example Structure |
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| 别名 |
border disease virus NS3 endopeptidase, BVD NS3 endopeptidase, BVDV NS3 endopeptidase, classical swine fever virus NS3 endopeptidase, CSFV NS3 endopeptidase, flavivirus NS3 protease, nonstructural protein 3, nonstructural protein NS3, NS2B/NS3 protease, NS3, NS3 protease, NS3 protein, NS3 proteinase, NS3 serine protease, NS3-SP, NS3prohelx, P80pestivirus P80 protein, S31.001, viral diarrhea virus endopeptidase, WNV NS2B/NS3 |
| EC Number |
3.4.21.113 |
| CAS编号 |
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| Comments |
The polyprotein of noncytopathogenic pestiviruses is cleaved co- and post-translationally into at least 11 proteins (Npro, C, Erns, E1, E2, p7, NS2-3, NS4A, NS4B, NS5A, and NS5B) [2]. The genomes of cytopathogenic pestivirus strains express at least one additional protein, called NS3 (p80) [2]. This enzyme, which resides in the N-terminal region of NS3 (nonstructural protein 3), is essential for generation of its own C-terminus and for processing of the downstream cleavage sites, leading to the release of the pestivirus nonstructural proteins NS4A, NS4B, NS5A and NS5B [1,2]. Belongs in peptidase family?S31. |
| Cofactor |
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| History |
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| Reactions |
Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1′ of the NS4A-NS4B cleavage site, whereas serine is found at position P1′ of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites. |
