phenylalanine N-monooxygenase EC#: 1.14.14.40; 凯望编码 (ChemWhat Code): 1375548
| 英文名 | phenylalanine N-monooxygenase |
| Example Structure | ![]() |
| 别名 | CYP79A1, CYP79A2, CYP79D16, cytochrome P450 79D16 |
| EC Number | 1.14.14.40 |
| CAS编号 | |
| Comments | This cytochrome P-450 (heme-thiolate) enzyme, found in plants, catalyses two successive N-hydroxylations of L-phenylalanine, a committed step in the biosynthesis of benzylglucosinolate and the cyanogenic glucosides (R)-prunasin and (R)-amygdalin. The product of the two hydroxylations, N,N-dihydroxy-L-phenylalanine, is labile and undergoes dehydration followed by decarboxylation, producing an oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme. |
| Cofactor | heme-thiolate |
| History | |
| Reactions | L-phenylalanine + 2 [reduced NADPH–hemoprotein reductase] + 2 O(2) = (E)-phenylacetaldoxime + 2 [oxidized NADPH–hemoprotein reductase] + CO(2) + 3 H(2)O. |
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