| 英文名 |
phosphomethylpyrimidine synthase |
| Example Structure |
 |
| 别名 |
2-methyl-4-amino-5-hydroxymethylpyrimidine phosphate synthase, 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase, AtTHIC, HMP phosphate synthase, HMP-P synthase, LeThiC, Thi5p, thiC |
| EC Number |
4.1.99.17 |
| CAS编号 |
|
| Comments |
Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable?S-adenosyl-L-methionine molecule. The first stage of catalysis is reduction of the?S-adenosyl-L-methionine to produce?L-methionine and a 5′-deoxyadenosin-5′-yl radical that is crucial for the conversion of the substrate. Part of the pathway for thiamine biosynthesis. |
| Cofactor |
iron-sulfur |
| History |
|
| Reactions |
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphomethyl)pyrimidine + 5′-deoxyadenosine + L-methionine + formate + Co. |
