| 英文名 |
pimeloyl-[acyl-carrier protein] synthase |
| Example Structure |
![Example Structure of pimeloyl-[acyl-carrier protein] synthase EC#: 1.14.14.46](/wp-content/uploads/enzyme-structure/1.14.14.46.jpg) |
| 别名 |
CYP107H1, cytochrome P450BioI, fatty acid hydroxylase, P450 BioI, P450BioI |
| EC Number |
1.14.14.46 |
| CAS编号 |
|
| Comments |
A cytochrome P450 (heme-thiolate) protein. The enzyme catalyses an oxidative C-C bond cleavage of long-chain acyl-[acyl-carrier protein]s of various lengths to generate pimeloyl-[acyl-carrier protein], an intermediate in the biosynthesis of biotin. The preferred substrate of the enzyme from the bacterium Bacillus subtilis is palmitoyl-[acyl-carrier protein] which then gives heptanal as the alkanal. The mechanism is similar to EC 1.14.15.6, cholesterol monooxygenase (side-chain-cleaving), followed by a hydroxylation step, which may occur spontaneously [2]. |
| Cofactor |
heme-thiolate |
| History |
|
| Reactions |
A long-chain acyl-[acyl-carrier protein] + 2 reduced flavodoxin + 3 O(2) = pimeloyl-[acyl-carrier protein] + an n-alkanal + 2 oxidized flavodoxin + 3 H(2)O. |
