| 英文名 |
precorrin-2 dehydrogenase |
| Example Structure |
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| 别名 |
cobaltochelatase, CysG, CysG enzyme, cysG gene product, EC 2.1.1.107, Met8p, precorrin-2 dehydrogenase, S-adenosyl-L-methionine(SAM)-dependent bismethyltransferase, dehydrogenase and ferrochelatase, SirC, siroheme synthetase |
| EC Number |
1.3.1.76 |
| CAS编号 |
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| Comments |
This enzyme catalyses the second of three steps leading to the formation of siroheme from uroporphyrinogen III. The first step involves the donation of two S-adenosyl-L-methionine-derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to form precorrin-2 (EC 2.1.1.107, uroporphyrin-III C-methyltransferase) and the third step involves the chelation of ferrous iron to sirohydrochlorin to form siroheme (EC 4.99.1.4, sirohydrochlorin ferrochelatase). In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p. In some bacteria, steps 1-3 are catalysed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirC being responsible for the above reaction. |
| Cofactor |
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| History |
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| Reactions |
Precorrin-2 + NAD(+) = sirohydrochlorin + Nadh. |
