preQ1 synthase EC#: 1.7.1.13; 凯望编码 (ChemWhat Code): 1374611
| 英文名 | preQ1 synthase |
| Example Structure |  |
| 别名 | 7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase, 7-cyano-7-deazaguanine reductase, NADPH-dependent 7-cyano-7-deazaguanine reductase, nitrile reductase, NRed, preQ0 reductase, preQ0oxidoreductase, QueF, queuine synthase, YkvM |
| EC Number | 1.7.1.13 |
| CAS编号 | 1256460-80-6 |
| Comments | The reaction occurs in the reverse direction. This enzyme catalyses one of the early steps in the synthesis of queosine (Q-tRNA), and is followed by the action of EC 2.4.2.29, tRNA-guanosine34 transglycosylase. Queosine is found in the wobble position of tRNAGUN in Eukarya and Bacteria [2] and is thought to be involved in translational modulation. The enzyme is not a GTP cyclohydrolase, as was thought previously based on sequence-homology studies. |
| Cofactor | |
| History | |
| Reactions | 7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-carbaguanine + 2 Nadph. |
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