| 别名 |
EGL-3/KPC2, More, Neuroendocrine convertase 2, PC2, PC2-like enzyme, PCSK2, pro-protein convertase-2, pro-protein convertase-2/carboxypeptidase-E, prohormone convertase, prohormone convertase 2, prohormone convertase-2, proneuropeptide convertase 2, proprotein convertase 2, proprotein convertase subtilisin/kexin-type 2 |
| Comments |
A Ca2+-dependent enzyme, maximally active at about pH 5.5. Specificity is broader than that of prohormone convertase 1. Substrates include pro-opiomelanocortin, proenkephalin, prodynorphin, proglucagon, proinsulin and proluteinizing-hormone-releasing-hormone. Does not hydrolyse prorenin or prosomatostatin, however. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 1. In peptidase family?S8?(subtilisin family). |
