| 别名 |
deglycase, DJ-1, DJ-1 protein, glutathione-independent glyoxalase, glutathione-independent glyoxalases, also called glyoxalases, glyoxalase, glyoxylase III, hchA, Hsp31, III, Maillard deglycase, More, PARK7, Parkinsonism-associated protein, Parkinsonism-associated protein DJ-1, PfpI, yajL, yhbO |
| Comments |
The enzyme, previously thought to be a glyoxalase, acts on glycated?L-arginine,?L-lysine, and?L-cysteine residues within proteins that have been attacked and modified by glyoxal or 2-oxopropanal. The attack forms hemithioacetal in the case of cysteines and aminocarbinols in the case of arginines and lysines. The enzyme repairs the amino acids, releasing glycolate or lactate (70-80% (S)-lactate and 20-30% (R)-lactate), depending on whether the attacking agent was glyoxal or 2-oxopropanal, respectively. |
