| 英文名 |
protein-fructosamine 3-kinase |
| Example Structure |
 |
| 别名 |
FL3P, FN3K, fructosamine 3 kinase, fructosamine 3-kinase, fructosamine-3-kinase, fructose-3-kinase, ketosamine 3-kinase 1 |
| EC Number |
2.7.1.171 |
| CAS编号 |
|
| Comments |
Nonenzymatic glycation is an important factor in the pathogenesis of diabetic complications. Key early intermediates in this process are fructosamines, such as [protein]-N6-D-fructosyl-L-lysine. Fructosamine-3-kinase is part of an ATP-dependent system for removing carbohydrates from nonenzymatically glycated proteins. The phosphorylation destablilizes the [protein]-N6-D-fructosyl-L-lysine adduct and leads to its spontaneous decomposition. cf. EC?2.7.1.172, protein-ribulosamine 3-kinase. |
| Cofactor |
|
| History |
|
| Reactions |
Atp + [protein]-N(6)-D-fructosyl-L-lysine = adp + [protein]-N(6)-(3-O- phospho-D-fructosyl)-L-lysine. |
