| 英文名 |
protein N-terminal asparagine amidohydrolase |
| Example Structure |
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| 别名 |
amidohydrolase for N-terminal asparagine, N-terminal amidase, N-terminal asparagine amidohydrolase, Nt-amidase, NTA1, NTAN1, NTAN1 amidase, NTAN1p amidase, NtN-amidase, PNAD, protein NH2-terminal asparagine deamidase, yNta1 |
| EC Number |
3.5.1.121 |
| CAS编号 |
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| Comments |
This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Asn. Following the acetylation and removal of the initiator methionine, the exposed N-terminal asparagine is deaminated, resulting in its conversion to?L-aspartate. The latter serves as a substrate for EC?2.3.2.8, arginyltransferase, making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. |
| Cofactor |
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| History |
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| Reactions |
N-terminal L-asparaginyl-[protein] + H(2)O = N-terminal L-aspartyl- [protein] + NH(3). |
