| 英文名 |
pteridine reductase |
| Example Structure |
 |
| 别名 |
EC 1.1.1.253, H region methotrexate resistance protein, LdPTR1, LmPTR1, NADPH-dependent short-chain dehydrogenase/reductase pteridine reductase, NADPH-dihydropteridine reductase, pteridine reductase, pteridine reductase 1, PTR1, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide phosphate), TbPTR1 |
| EC Number |
1.5.1.33 |
| CAS编号 |
131384-61-7 |
| Comments |
The enzyme from Leishmania (both amastigote and promastigote forms) catalyses the reduction by NADPH of folate and a wide variety of unconjugated pterins, including biopterin, to their tetrahydro forms. It also catalyses the reduction of 7,8-dihydropterins and 7,8-dihydrofolate to their tetrahydro forms. In contrast to EC 1.5.1.3 (dihydrofolate reductase) and EC 1.5.1.34 (6,7-dihydropteridine reductase), pteridine reductase will not catalyse the reduction of the quinonoid form of dihydrobiopterin. The enzyme is specific for NADPH; no activity has been detected with NADH. It also differs from EC 1.5.1.3 in being specific for the B side of NADPH. |
| Cofactor |
|
| History |
|
| Reactions |
5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = biopterin + 2 Nadph. |
