| 英文名 |
Pup amidohydrolase |
| Example Structure |
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| 别名 |
deamidase of Pup, deamidase/depupylase Dop, depupylase, depupylase/deamidase, Dop, DPUP, Pup deamidase, Rv2112, Rv2112c |
| EC Number |
3.5.1.119 |
| CAS编号 |
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| Comments |
The enzyme has been characterized from the bacterium?Mycobacterium tuberculosis. It catalyses the hydrolysis of the amido group of the C-terminal glutamine of prokaryotic ubiquitin-like protein (Pup), thus activating it for ligation to target proteins, a process catalysed by EC?6.3.1.19, prokaryotic ubiquitin-like protein ligase. Deamination requires ATP as cofactor but not its hydrolysis. The enzyme also catalyses the hydrolytic cleavage of the bond formed by the ligase, between an ¦Å-amino group of a lysine residue of the target protein and the ¦Ã-carboxylate of the C-terminal glutamate of the prokaryotic ubiquitin-like protein. |
| Cofactor |
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| History |
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| Reactions |
[Prokaryotic ubiquitin-like protein]-L-glutamine + H(2)O = [prokaryotic ubiquitin-like protein]-L-glutamate + NH(3). |
