| 英文名 |
pyrimidine-nucleoside phosphorylase |
| Example Structure |
 |
| 别名 |
phosphorylase, pyrimidine nucleoside, Py-NPase, PYNP, pynpase, pyrimidine nucleoside phosphorylase, pyrimidine ribonucleoside phosphorylase, TTHA1771 |
| EC Number |
2.4.2.2 |
| CAS编号 |
9055-35-0 |
| Comments |
Unlike EC 2.4.2.3, uridine phosphorylase, EC 2.4.2.4, and thymidine phosphorylase, this enzyme can accept both the ribonucleoside uridine and the 2′-deoxyribonucleosides 2′-deoxyuridine and thymidine [3]. The reaction is reversible, and the enzyme does not distinguish between ¦Á-D-ribose 1-phosphate and 2-deoxy-¦Á-D-ribose 1-phosphate in the synthetic direction. |
| Cofactor |
|
| History |
|
| Reactions |
(1) Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. (2) Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. (3) 2′-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate. |
