| 英文名 |
quinolinate synthase |
| Example Structure |
 |
| 别名 |
Fe4S4 quinolinate synthase, NadA, Old5, PfQS, quinolinate synthetase, SufE3 |
| EC Number |
2.5.1.72 |
| CAS编号 |
|
| Comments |
An iron-sulfur protein that requires a [4Fe-4S] cluster for activity [1]. Quinolinate synthase catalyses the second step in the de novo biosynthesis of NAD+ from aspartate in some bacteria, with EC 1.4.3.16 (L-aspartate oxidase) catalysing the first step and EC 2.4.2.19 [nicotinate-nucleotide diphosphorylase (carboxylating)] the third step. In Escherichia coli, two of the residues that are involved in the [4Fe-4S] cluster binding appear to undergo reversible disulfide-bond formation that regulates the activity of the enzyme [5]. |
| Cofactor |
iron-sulfur |
| History |
|
| Reactions |
Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H(2)O + phosphate. |
