(R)-(-)-2-Amino-1-propanol CAS#: 35320-23-1; 凯望编码 (ChemWhat Code): 86858

IdentificationPhysical DataSpectra
Route of Synthesis (ROS)Safety and HazardsOther Data

Identification

英文名(R)-(-)-2-Amino-1-propanol
IUPAC Name(2R)-2-aminopropan-1-ol
分子结构R-2-Amino-1-propanol-CAS-35320-23-1
CAS编号 35320-23-1
MDL NumberMFCD00064413
别名d-Alaninol
35320-23-1
(R)-(-)-2-Amino-1-propanol
(R)-2-Aminopropan-1-ol
(2R)-2-aminopropan-1-ol
(R)-2-amino-1-propanol
(R)-Alaninol
2-Aminopropanol, (-)-
(R)-2-aminopropanol
(-)-2-aminopropanol
1-Propanol, 2-amino-, (2R)-
H-D-Ala-ol
d-2-amino-1-propanol
770ZI70L3Q
(2r)-2-amino-1-propanol
R-2-Amino-1-propanol
H-D-Alaninol
2-Amino-propan-1-ol
D-2-amino-propanol
UNII-770ZI70L3Q
MFCD00064413
(d)-alaninol
(-)-alaninol
2(R)-aminopropanol
2-Amino-1-propanol #
Spectrum2_000831
Spectrum3_001969
(2R)-2-amino propanol
(R)-2-aminopropan-1ol
R-(-)-ALANINOL
(-)-2-amino-1-propanol
(R)-2-amino-propan-1-ol
(R)-2-aminopropan -1-ol
BSPBio_003569
(2R)-2-azanylpropan-1-ol
(R)-1-hydroxymethylethylamine
SPBio_000781
KBio3_002920
DTXSID30904764
(A+/-)-2-amino-propan-1-ol
(R)-(+)-2-amino-1-propanol
CHEBI:195478
(R) -(-)-2-amino-1-propanol
CCG-40291
AKOS006240049
AKOS015840241
CS-W011362
HY-W010646
NCGC00177987-01
(R)-(-)-2-Amino-1-propanol, 98%
AC-24153
((R)-2-HYDROXY-1-METHYLETHYL)AMINE
A6201
AM20090557
EN300-33361
A-4546
M03439
A1-00441
Q27266526
Z346076140
2A3
分子式C3H9NO
分子量75.11
InChIInChI=1S/C3H9NO/c1-3(4)2-5/h3,5H,2,4H2,1H3/t3-/m1/s1
InChI KeyBKMMTJMQCTUHRP-GSVOUGTGSA-N
Isomeric SMILESC[C@H](CO)N
Patent Information
Patent IDTitlePublication Date
CN116003406Heteroaromatic ring oxynitride and preparation method and application thereof2023
CN115215799Urea multi-target tyrosine kinase inhibitor and various medical applications thereof2022
US2021/139454FORMAMIDE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF2021
US2020/34708NOVEL PROBE COMPOUNDS FOR FLUORESCENCE AND/OR CIRCULAR DICHROISM SENSOR FOR AMINE COMPOUNDS INCLUDING AMINO ALCOHOLS, AND SIMULTANEOUS ANALYSIS METHOD OF FLUORESCENCE AND CIRCULAR DICHROISM2020
WO2019/1016412-HETARYLPYRIMIDINE-4-CARBOXAMIDES AS ARYL HYDROCARBON RECEPTOR ANATGONISTS2019

Physical Data

AppearanceSlightly yellow to clear liquid

Spectra

Description (NMR Spectroscopy)Nucleus (NMR Spectroscopy)Solvents (NMR Spectroscopy)Frequency (NMR Spectroscopy), MHz
Chemical shifts1Hchloroform-d1
Chemical shifts1Hdimethylsulfoxide-d6400
Chemical shifts1Hchloroform-d1400
Chemical shifts1HCDCl3
Description (IR Spectroscopy)Solvent (IR Spectroscopy)
Spectrumneat (no solvent)
BandsCDCl3
Bandssolid Ar
Description (UV/VIS Spectroscopy)Absorption Maxima (UV/VIS), nm
in the presence of organic compounds567

Route of Synthesis (ROS)

Route of Synthesis (ROS) of (R)-(-)-2-Amino-1-propanol CAS# 35320-23-1
Route of Synthesis (ROS) of (R)-(-)-2-Amino-1-propanol CAS# 35320-23-1
ConditionsYield
With triethylamine In methanol at 0 – 20℃; for 12h;

Experimental Procedure
4.1.44. tert-Butyl (R)-(1-hydroxypropan-2-yl)carbamate (42)
To a solution of (R)-()-2-amino-1- propanol 36 (2.00 g,26.6 mmol) and triethylamine (4.27 mL, 30.6 mmol) in MeOH(20 mL) at 0 C was added di-tert-butyl dicarbonate (6.42 g,29.4 mmol). After stirring at room temperature for 12 h, the solventwas evaporated in vacuo. The residuewas diluted with CH2Cl2. Afterwashing with water, the organic phase was evaporated to drynessfurnishing the title compound (4.60 g, 100%), which was usedwithout further purification in the next step. 1H NMR (300 MHz,CDCl3) d 4.91 (d, J 6.3 Hz, 1H), 3.70 (s, 1H), 3.56 (dt, J 10.8, 5.6 Hz,1H), 3.45 (dd, J 11.5, 5.6 Hz, 2H), 1.39 (s, 9H), 1.10 (d, J 6.8 Hz,3H). 13C NMR (75 MHz, CDCl3) d 156.91 (s), 80.15 (s), 67.46 (s), 49.05(s), 28.99 (s), 17.92 (s).		100%
With sulfonic-acid-functionalized silica In dichloromethane at 20℃; for 0.166667h;95%
With triethylamine In tetrahydrofuran at 0 – 20℃; for 18h;

Experimental Procedure
A solution of 10 gm (133 mMol) (R)-2-amino-1-propanol and 14.8 gm (146.5 mMol) triethylamine in 500 mL tetrahydrofuran was cooled to 0° C. To this solution was added all at once 30 gm (133 mMol) di-tert-butyl dicarbonate. The reaction mixture was allowed to stir for about 18 hours at room temperature. The reaction mixture was then concentrated under reduced pressure and the resulting residue was dissolved in 300 mL ethyl acetate. This solution was washed twice with 200 mL of water, once with 200 mL of saturated aqueous sodium chloride, dried over magnesium sulfate and concentrated under reduced pressure to provide 22 gm (94%) of the desired compound as a yellow oil.1H-NMR(CDCl3): δ 4.71 (m, 1H), 3.72 (m, 1H), 3.59-3.46 (m, 2H), 2.86 (m, 1H).		94%

Safety and Hazards

Pictogram(s)corrosion
SignalDanger
GHS Hazard StatementsH314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
Precautionary Statement CodesP260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)

Other Data

TransportationStore at room temperature, in container tightly sealed; Protect from light.
HS Code
StorageStore at room temperature, in container tightly sealed; Protect from light.
Shelf Life2 years
Market Price
Druglikeness
Lipinski rules component
分子量75.1106
logP-0.815
HBA2
HBD2
Matching Lipinski Rules4
Veber rules component
Polar Surface Area (PSA)46.25
Rotatable Bond (RotB)1
Matching Veber Rules2
Use Pattern
(R)-(-)-2-Amino-1-propanol CAS 35320-23-1 as an intermediate in organic synthesis, it is used for the synthesis of emulsifiers, surfactants, dyes, rubber stabilizers, and other organic compounds. In the pharmaceutical field, D-Aminopropanol is commonly used as a pharmaceutical intermediate for the synthesis of various drugs, such as beta-blockers, adrenergic agonists, and others.

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