| 英文名 |
renalase |
| Example Structure |
 |
| 别名 |
alphaNAD(P)H oxidase/anomerase, REN, Ren-1, Ren-2, renalase-1, renalase-2 |
| EC Number |
1.6.3.5 |
| CAS编号 |
|
| Comments |
Requires FAD. Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of ¦Â-NAD(P)H back to ¦Â-NAD(P)+. These isomeric forms, generated by nonspecific reduction of ¦Â-NAD(P)+ or by tautomerization of ¦Â-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration. |
| Cofactor |
FAD |
| History |
|
| Reactions |
(1) 1,2-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2). (2) 1,6-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2). |
