RING-type E3 ubiquitin transferase EC#: 2.3.2.27; 凯望编码 (ChemWhat Code): 1377188

英文名 RING-type E3 ubiquitin transferase
Example Structure Example Structure of RING-type E3 ubiquitin transferase EC#: 2.3.2.27
别名 ABA-insensitive RING protein3, abscisic acid-insensitive RING protein 4, ACRE276, AIRP1, AIRP2, AIRP3, AIRP4, AMFR, Arabidopsis ABA-insensitive RING protein 1, Arabidopsis ABA-insensitive RING protein 2, ARIH1, At1g54150, At1g74410, At2g15580, At4g23450, ATL2, ATL80, Avr9/Cf-9 rapidly elicited protein 276, BRCA1, BRE1B, breast cancer susceptibility protein 1, c-Cbl, C3HC4-RING finger E3 ubiquitin ligase, CaRING1, CHIP, Cop1, COP1 SUPPRESSOR1, CSU1, CUL4, cullin-4, DAF, DEAR1, DEFECTIVE IN ANTHER DEHISCENCE1 (DAD1)-activating factor, Der3, E3 ligase, E3 ubiquitin ligase, E3 ubiquitin ligase Erysiphe necator-induced RING finger protein 1, E3 ubiquitin ligase RING1, E3 ubiquitin-protein ligase Mdm2, E3 ubiquitin-protein ligase MIR1, E3 ubiquitin-protein ligase RNF25, E3-enzyme, EIRP1, ERAD-associated E3 ubiquitin-protein ligase DOA10, ERAD-associated E3 ubiquitin-protein ligase HRD1, gamma rays-induced RING finger protein1, GIRP1, gp78, H2-10, HCI1, HHARI, HIR1, HSPC238, HTAS, HUB1, Human Homologue of Drosophila Ariadne, IDF1, IRT1 degradation factor1, KEEP ON GOING, KEG, Kf-1, LOG2, mahogunin ring finger-1, MARCH10, MARCH6, Mdm2, MGRN1, microtubule-associated E3 ubiquitin ligase isoform 1, NERF, NFYA5 enhancing RING FINGER, Os10g30850, Parkin, Parkinson juvenile disease protein 2, Pirh2, PLANT U-BOX17, pre-mRNA-splicing factor 19, PRP19, PUB17, PUB54, RanBP-type and C3HC4-type zinc finger-containing protein 1, RBCK1, RFP1, RFPH2-10, RGLG2, RHA2b, Rines, RING E3, RING E3 ubiquitin ligase, ring finger protein 103, Ring finger protein 186, RING finger ubiquitin E3 ligase, RING-CH 10, ring-finer protein 55, RING-finger E3 ligase, RING-finger E3 ubiquitin ligase, RING-finger ubiquitin ligase Ubr1, RING-H2 finger E3 ubiquitin ligase, RING-H2 finger protein ATL63, RING-IBR-RING ubiquitin ligase, RING-type E3 ligase, RING-type E3 ubiquitin ligase, Ring1B, RMA1, RMA2, RMA3, RN181, RNF103, RNF180, RNF186, RNF190, RNF2, RNF220, RNF4, RNF43, RNF45, RNF8, salt tolerance RING finger 1, SDIR1, Sis3, SSM4, STIP1 homology and U-Box containing protein 1, Strf1, TEB4, TRIM22, TRIM25, TRIM3, TRIM5, TRIM5alpha, TRIM62, TRIM69, tripartite motif-containing protein 5, U-box domain-containing protein 17, ubiquitin ligase E3, ubiquitin ligase Ubr1, ubiquitin-protein ligase K3, UBR1, Xbat32
EC Number 2.3.2.27
CAS编号
Comments RING E3 ubiquitin transferases serve as mediators bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) and an acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the ¦Å-amino group of an L-lysine residue of the acceptor protein. Unlike EC 2.3.2.26, HECT-type E3 ubiquitin transferase, the RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin. Many members of the RING-type E3 ubiquitin transferase family are not able to bind a substrate directly, and form a complex with a cullin scaffold protein and a substrate recognition module (the complexes are named CRL for Cullin-RING-Ligase). In these complexes, the RING-type E3 ubiquitin transferase provides an additional function, mediating the transfer of a NEDD8 protein from a dedicated E2 carrier to the cullin protein (see EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase). cf. EC 2.3.2.31, RBR-type E3 ubiquitin transferase. Formerly EC 6.3.2.19 and EC 6.3.2.21.
Cofactor
History
Reactions S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine.

试剂采购

没有试剂厂商? 向凯望发送快速询价
想要被列为试剂厂商? (付费服务) 点击这里联系凯望

认证生产商

想要被列为认证生产商 (需要通过认证)? 请下载并填写 这份表格并发邮件到approved-manufacturers@chemwhat.com

其他供应商

Watson International Limited 访问Watson官网

如需其他帮助，请联系我们

联系我们获取其它信息或服务 点击这里联系凯望