| 英文名 |
(S)-2-hydroxypropylphosphonic acid epoxidase |
| Example Structure |
 |
| 别名 |
(S)-2-HPP epoxidase, (S)-2-hydroxypropylphosphonic acid epoxidase, (S-HPP) epoxidase, 2-hydroxypropylphosphonic acid epoxidase, fom4, fosfomycin-producing epoxidase, HPP epoxidase, HppE, Ps-HppE |
| EC Number |
1.11.1.23 |
| CAS编号 |
|
| Comments |
This is the last enzyme in the biosynthetic pathway of fosfomycin, a broad-spectrum antibiotic produced by certain Streptomyces species. Contains non heme iron that forms a iron(IV)-oxo (ferryl) complex with hydrogen peroxide, which functions as a proton abstractor from the substrate [7]. |
| Cofactor |
Fe cation |
| History |
|
| Reactions |
(S)-2-hydroxypropylphosphonate + H(2)O(2) = (1R,2S)-1,2- epoxypropylphosphonate + 2 H(2)O. |
