| 英文名 |
sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) |
| Example Structure |
 |
| 别名 |
AKR1B1, MDSPR, reductase, sepiapterin, sepiapterin reductase, SPR, SR |
| EC Number |
1.1.1.153 |
| CAS编号 |
9059-48-7 |
| Comments |
This enzyme catalyses the final step in the de novo synthesis of tetrahydrobiopterin from GTP. The enzyme, which is found in higher animals and some fungi and bacteria, produces the erythro form of tetrahydrobiopterin. cf. EC 1.1.1.325, sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming). |
| Cofactor |
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| History |
|
| Reactions |
(1) L-erythro-7,8-dihydrobiopterin + NADP(+) = sepiapterin + Nadph. (2) L-erythro-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8- tetrahydropterin + 2 Nadph. |
