Signal peptidase I EC#: 3.4.21.89; 凯望编码 (ChemWhat Code): 1380617

英文名 Signal peptidase I
Example Structure Example Structure of Signal peptidase I EC#: 3.4.21.89
别名 Bacterial leader peptidase 1, bacterial type I signal peptidase, big signal peptidase, canine signal peptidase complex, EC 3.4.99.36, Escherichia coli leader peptidase, Eukaryotic signal peptidase, Eukaryotic signal proteinase, hen oviduct signal peptidase, HOSP, imp1p, Leader peptidase, Leader peptidase I, Leader peptide hydrolase, Leader proteinase, LEP, LepB, PA1303, Pcp1, Peptidase, signal, Pilin leader peptidase, plastidic SPase I, plastidic type I signal peptidase 1, Plsp1, Prokaryotic leader peptidase, Prokaryotic signal peptidase, Prokaryotic signal proteinase, Propeptidase, protease IV, Proteinase, eukaryotic signal, Proteinase, signal, PuIO prepilin peptidase, Rv2903c, Signal peptidase, signal peptidase I, signal peptidase type I, Signal peptide hydrolase, Signal peptide peptidase, Signalase, Sip1, Sip2, Sip3, SipP (pTA1015), SipP (pTA1040), SipS, SipT, SipU, SipV, SipW, SipX, SipY, SipZ, SP, SP-I, SPase, Spase I, SPaseI, SPC, Spc1, SPP, SpsB, thylakoidal processing peptidase, TPP, type I signal (leader) peptidase, type I signal peptidase, type I signal peptidase Sec11a, type I signal peptidase Sec11b, type I SPase
EC Number 3.4.21.89
CAS编号 65979-36-4
Comments Present in the inner membrane of?Escherichia coli. Unaffected by inhibitors of most serine peptidases, but site-directed mutagenesis implicates a Ser/Lys catalytic dyad in activity [1, 3]. Hydrolyses a single bond -Ala©àAla- in M13 phage procoat protein, producing free signal peptide and coat protein. Formerly included in EC?3.4.99.36. Eukaryote signal peptidases that may have somewhat different specificity are known from the endoplasmic reticulum membrane [4] and mitochondrial inner membrane [2]. Type example of peptidase family?S26.
Cofactor
History
Reactions Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

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