| 英文名 |
single-stranded DNA cytosine deaminase |
| Example Structure |
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| 别名 |
activation-induced cytidine deaminase, activation-induced deaminase, AICDA, AID |
| EC Number |
3.5.4.38 |
| CAS编号 |
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| Comments |
The enzyme exclusively catalyses deamination of cytosine in single-stranded DNA. It preferentially deaminates five-nucleotide bubbles. The optimal target consists of a single-stranded NWRCN motif (W = A or T, R = A or G) [2]. The enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences. |
| Cofactor |
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| History |
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| Reactions |
Cytosine in single-stranded Dna + H(2)O = uracil in single-stranded dna + NH(3). |
