| 英文名 |
sirohydrochlorin ferrochelatase |
| Example Structure |
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| 别名 |
CbiX, CysG, Met8p, More, SirB, sirohydrochlorin ferrochelatase, sirohydrochlorin-ferrochelatase |
| EC Number |
4.99.1.4 |
| CAS编号 |
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| Comments |
This enzyme catalyses the third of three steps leading to the formation of siroheme from uroporphyrinogen III. The first step involves the donation of two?S-adenosyl-L-methionine-derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to form precorrin-2 (EC?2.1.1.107, uroporphyrin-III C-methyltransferase) and the second step involves an NAD+-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC?1.3.1.76, precorrin-2 dehydrogenase). In?Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p. In some bacteria, steps 1-3 are catalysed by a single multifunctional protein called CysG, whereas in?Bacillus megaterium, three separate enzymes carry out each of the steps, with SirB being responsible for the above reaction. |
| Cofactor |
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| History |
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| Reactions |
Siroheme + 2 H(+) = sirohydrochlorin + Fe(2+). |
