[Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase EC#: 2.4.1.229 • ChemWhat中文网

[Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase EC#: 2.4.1.229; 凯望编码 (ChemWhat Code): 1377535


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英文名	[Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase
Example Structure
别名	acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-glycoprotein serine/threonine, acetylglucosaminyltransferase, uridine diphosphoacetylglucose-protein Skp1 hydroxyproline, Dd-ppGnT1, GnT1, GnT51, hydroxyproline-capping enzyme, Skp1 alpha-GlcNAcT1, Skp1 alpha-GlcNAcT1-like enzyme, Skp1-HyPro GlcNAc-transferase, UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase, UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase, UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase
EC Number	2.4.1.229
CAS编号
Comments	Skp1 is a cytoplasmic and nuclear protein required for the ubiquitination of cell cycle regulatory proteins and transcriptional factors. In Dictyostelium Skp1 is modified by the linear pentasaccharide Gal¦Á1-6Gal¦Á1-L-Fuc¦Á1-2Gal¦Â1-3GlcNAc, which is attached to a hydroxyproline residue at position 143. This enzyme catalyses the first step in the building up of the pentasaccharide by attaching an N-acetylglucosaminyl group to the hydroxyproline residue. It requires dithiothreitol and a divalent cation for activity.
Cofactor	divalent metal cation
History
Reactions	UDP-N-acetyl-alpha-D-glucosamine + [Skp1-protein]-trans-4-hydroxy-L- proline = Udp + [Skp1-protein]-O-(N-acetyl-alpha-D-glucosaminyl)-trans-4- hydroxy-L-proline.