| 英文名 |
sn-glycerol-1-phosphate dehydrogenase |
| Example Structure |
 |
| 别名 |
EgsA, Enantiomeric glycerophosphate synthase, G-1-P dehydrogenase, G-1-P-dehydrogenase, G1PDH, Gro1PDH, NAD(P)H-dependent G1P dehydrogenase, sn-glycerol-1-phosphate dehydrogenase, ST0344 protein, Zn2+-dependent sn-glycerol-1-phosphate dehydrogenase |
| EC Number |
1.1.1.261 |
| CAS编号 |
204594-18-3 |
| Comments |
This enzyme is found primarily as a Zn2+-dependent form in archaea but a Ni2+-dependent form has been found in Gram-positive bacteria [7]. The Zn2+-dependent metalloenzyme is responsible for the formation of archaea-specific sn-glycerol-1-phosphate, the first step in the biosynthesis of polar lipids in archaea^. It is the enantiomer of sn-glycerol 3-phosphate, the form of glycerophosphate found in bacteria and eukaryotes. The other enzymes involved in the biosynthesis of polar lipids in archaea are EC 2.5.1.41 (phosphoglycerol geranylgeranyltransferase) and EC 2.5.1.42 (geranylgeranylglycerol-phosphate geranylgeranyltransferase), which together alkylate the hydroxy groups of glycerol 1-phosphate to give unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 (CDP-archaeol synthase) to form CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [5]. Activity of the enzyme is stimulated by K+ [2]. |
| Cofactor |
Zn2+ or Ni2+ |
| History |
|
| Reactions |
sn-glycerol 1-phosphate + NAD(P)(+) = glycerone phosphate + NAD(P)H. |
