Sotorasib CAS#: 2296729-00-3; 凯望编码 (ChemWhat Code): 1417439

IdentificationPhysical DataSpectra
Route of Synthesis (ROS)Safety and HazardsOther Data

Identification

英文名Sotorasib
IUPAC Name6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one  
分子结构3-Aminopyridine-CAS-462-08-8
CAS编号 2296729-00-3
MDL NumberMFCD32880274
别名otorasib
AMG-510
2296729-00-3
AMG510
Lumakras
AMG-510 racemate
2252403-56-6
AMG 510
Kras G12C inhibitor 9
sotorasibum
4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one
Kras mutant-targeting AMG 510
2B2VM6UC8G
Sotorasib [INN]
Sotorasib [USAN]
UNII-2B2VM6UC8G
CHEMBL4535757
CHEBI:178199
2296729-00-3 (racemate)
分子式C30H30F2N6O3
分子量560.6
InChIInChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1 
InChI KeyNXQKSXLFSAEQCZ-SFHVURJKSA-N
Canonical SMILESC[C@H]1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C

Physical Data

No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

Use Pattern
Sotorasib CAS#: 2296729-00-3 is a selective covalent inhibitor of KRAS G12C for the treatment of patients with advanced KRAS G12C mutated non-small cell lung cancer (NSCLC) who have received prior systemic therapy.

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