| 英文名 |
sphingolipid 8-(E)-desaturase |
| Example Structure |
 |
| 别名 |
8 fatty acid desaturase, 8-sphingolipid desaturase, D8A, D8B, D8C, D8D, DELTA8-sphingolipid desaturase, DesB, SLD, sphinganine DELTA8-desaturase |
| EC Number |
1.14.19.18 |
| CAS编号 |
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| Comments |
The enzyme, characterized from the yeasts Kluyveromyces lactis and Candida albicans [1] and from the diatom Thalassiosira pseudonana [2], introduces a trans double bond at the 8-position of sphingoid bases in sphingolipids. The enzyme determines the position of the double bond by its distance from the alcohol end of the sphingoid base, and contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase [3]. The homologous enzymes from higher plants, EC 1.14.19.29, sphingolipid 8-(E/Z)-desaturase, act on phytosphinganine (4-hydroxysphinganine) and produces a mixture of trans and cis isomers. |
| Cofactor |
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| History |
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| Reactions |
A (4E)-sphing-4-enine ceramide + 2 ferrocytochrome b5 + O(2) + 2 H(+) = a (4E,8E)-sphing-4,8-dienine ceramide + 2 ferricytochrome b5 + 2 H(2)O. |
