sphingomyelin synthase EC#: 2.7.8.27; 凯望编码 (ChemWhat Code): 1378957
| 英文名 | sphingomyelin synthase |
| Example Structure |  |
| 别名 | PC:ceramide cholinephosphotransferase, PC:ceramide phosphocholinetransferase, phosphatidylcholine:ceramide cholinephosphotransferase 1, phosphatidylcholine:ceramide cholinephosphotransferase 2, PlcH, SGMS, SGMS1, Sgms2, SM synthase, SM synthase 1, SMS, SMS1, SMS1-related enzyme, SMS2, SMSr, sphingomyelin synthase 1, sphingomyelin synthase 2, sphingomyelin synthase-related protein, sphingomyelin synthases 1, sphingomyelin synthases 2, sphingomyelin-synthase |
| EC Number | 2.7.8.27 |
| CAS编号 | |
| Comments | The reaction can occur in both directions [3]. This enzyme occupies a central position in sphingolipid and glycerophospholipid metabolism [4]. Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signalling in a variety of mammalian cell types [4]. Unlike EC?2.7.8.3, ceramide cholinephosphotransferase, CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin [2]. |
| Cofactor | |
| History | |
| Reactions | A ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl- sn-glycerol. |
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