| 英文名 |
SpoIVB peptidase |
| Example Structure |
 |
| 别名 |
M50.002, S55.001, SpoIVB, SpoIVB serine peptidase, SpolVFB, sporulation protein SpolVFB, stage IV sporulation protein FB |
| EC Number |
3.4.21.116 |
| CAS编号 |
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| Comments |
This enzyme plays a central role in a regulatory checkpoint (the ¦ÒK?checkpoint), which coordinates gene expression during the later stages of spore formation in?Bacillus subtilis?[1,3]. The enzyme activates proteolytic processing of a sporulation-specific sigma factor, pro-¦ÒK, to its mature and active form, ¦ÒK, by self-cleavage [1,3]. The enzyme is also subject to secondary proteolysis, which presumably inactivates SpoIVB [3]. The enzyme is also essential for the formation of heat-resistant spores. Belongs in peptidase family?S55. |
| Cofactor |
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| History |
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| Reactions |
Self-cleaves 52-Val-|-Asn-53, 62-Ala-|-Phe-63 and 74-Val-|-Thr-75 at the N-terminus of SpoIVB. |
