| 英文名 |
succinylornithine transaminase |
| Example Structure |
 |
| 别名 |
AstC, More, N2-succinylornithine 5-aminotransferase, SOAT, SOT, succinylornithine 5-aminotransferase, succinylornithine aminotransferase |
| EC Number |
2.6.1.81 |
| CAS编号 |
|
| Comments |
A pyridoxal-phosphate protein. Also acts on?N2-acetyl-L-ornithine and?L-ornithine, but more slowly [3]. In?Pseudomonas aeruginosa, the arginine-inducible succinylornithine transaminase, acetylornithine transaminase (EC?2.6.1.11) and ornithine aminotransferase (EC?2.6.1.13) activities are catalysed by the same enzyme, but this is not the case in all species [5]. This is the third enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC?2.3.1.109?(arginine?N-succinyltransferase), EC?3.5.3.23?(N-succinylarginine dihydrolase), EC?2.6.1.81?(succinylornithine transaminase), EC?1.2.1.71?(succinylglutamate-semialdehyde dehydrogenase) and EC?3.5.1.96?(succinylglutamate desuccinylase) [3, 6]. |
| Cofactor |
pyridoxal 5′-phosphate |
| History |
|
| Reactions |
N(2)-succinyl-L-ornithine + 2-oxoglutarate = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate. |
