| 英文名 |
tetracenomycin A2 monooxygenase-dioxygenase |
| Example Structure |
 |
| 别名 |
ElmG, Tcm A2 oxygenase, Tcm B2 oxygenase, TcmG, tetracenomycin A2 oxygenase |
| EC Number |
1.14.13.200 |
| CAS编号 |
|
| Comments |
Isolated from the bacterium Streptomyces glaucescens. The enzyme was also isolated from the bacterium Streptomyces olivaceus, where it acts on 8-demethyltetracenomycin A2 (tetracenomycin B2) as part of elloramycin biosynthesis. The reaction involves a monooxygenase reaction which is followed by a dioxygenase reaction giving a gem-diol and an epoxide. Water opens the epoxide giving two hydroxy groups. The gem-diol eliminates water to give a ketone which is then reduced to a hydroxy group. |
| Cofactor |
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| History |
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| Reactions |
Tetracenomycin A2 + 2 O(2) + 2 NAD(P)H = tetracenomycin C + 2 NAD(P)(+) + H(2)O. |
