| 英文名 |
tetracenomycin F2 synthase |
| Example Structure |
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| 别名 |
TCM F2, TCM PKS, TcmK protein, TcmN polyketide cyclase, type II polyketide synthase |
| EC Number |
2.3.1.235 |
| CAS编号 |
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| Comments |
A multi-domain polyketide synthase involved in the synthesis of tetracenomycin in the bacterium Streptomyces glaucescens. It involves a ketosynthase complex (TcmKL), an acyl carrier protein (TcmM), a malonyl CoA:ACP acyltransferase (MAT), and a cyclase (TcmN). A malonyl-CoA molecule is initially bound to the acyl carrier protein and decarboxylated to form an acetyl starter unit. Additional two-carbon units are added from nine more malonyl-CoA molecules. |
| Cofactor |
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| History |
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| Reactions |
10 malonyl-CoA = tetracenomycin F2 + 10 CoA + 10 CO(2) + 2 H(2)O. |
