| 英文名 |
tetracycline 11a-monooxygenase |
| Example Structure |
 |
| 别名 |
BN1088_100004, tetracycline resistance protein from transposon Tn4351/Tn4400, tetracylcine resistance protein TetX, TetX, TetX family tetracycline inactivation enzyme, TetX2 |
| EC Number |
1.14.13.231 |
| CAS编号 |
|
| Comments |
A flavoprotein (FAD). This bacterial enzyme confers resistance to all clinically relevant tetracyclines when expressed under aerobic conditions. The hydroxylated products are very unstable and lead to intramolecular cyclization and non-enzymic breakdown to undefined products. |
| Cofactor |
FAD |
| History |
|
| Reactions |
Tetracycline + Nadph + O(2) = 11a-hydroxytetracycline + NADP(+) + H(2)O. |
