| 英文名 |
tetracycline polyketide synthase |
| Example Structure |
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| 别名 |
minimal PKS, octaketide minimal PKS, otc PKS, oxy, OxyA, oxyABC, OxyB, OxyC, oxytetracycline PKS, oxytetracycline polyketide synthase, type II minimal polyketide synthase, type II PKS |
| EC Number |
2.3.1.260 |
| CAS编号 |
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| Comments |
The synthesis, in the bacterium Streptomyces rimosus of the tetracycline antibiotics core skeleton requires a minimal polyketide synthase (PKS) consisting of a ketosynthase (KS), a chain length factor (CLF), and an acyl-carrier protein (ACP). Initiation involves an amide-containing starter unit that becomes the C-2 amide that is present in the tetracycline compounds. Following the initiation, the PKS catalyses the iterative condensation of 8 malonyl-CoA molecules to yield the polyketide backbone of tetracycline. Throughout the proccess, the nascent chain is attached to the OxyC acyl-carrier protein. |
| Cofactor |
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| History |
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| Reactions |
Malonamoyl-[OxyC acyl-carrier protein] + 8 malonyl-CoA = 18-carbamoyl- 3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC acyl-carrier protein] + 8 CO(2) + 8 CoA. |
