| 英文名 |
tRNA (cytosine34-C5)-methyltransferase |
| Example Structure |
 |
| 别名 |
cytosine-5 RNA methyltransferase, hTrm4, NOP2/Sun domain family member 2, NSUN2, RNA:m5C methyltransferase, SAKI, substrate of AIM-1/Aurora kinase B |
| EC Number |
2.1.1.203 |
| CAS编号 |
|
| Comments |
The human enzyme is specific for C5-methylation of cytosine34 in tRNA precursors. The intron in the human pre-tRNALeu(CAA) is indispensable for the C5-methylation of cytosine in the first position of the anticodon. It is not able to form 5-methylcytosine at positions 48 and 49 of human and yeast tRNA precursors [1]. |
| Cofactor |
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| History |
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| Reactions |
S-adenosyl-L-methionine + cytosine(34) in tRNA precursor = S-adenosyl-L- homocysteine + 5-methylcytosine(34) in tRNA precursor. |
