| 英文名 |
tRNA uracil 4-sulfurtransferase |
| Example Structure |
 |
| 别名 |
Ctu1, MMP1354, ribonucleate sulfurtransferase, RNA sulfurtransferase, ThiI, thiouridylase, transfer ribonucleate sulfurtransferase, transfer RNA sulfurtransferase, transferRNA thiolase, tRNA thiolase, wobble uridine-34 thiolase |
| EC Number |
2.8.1.4 |
| CAS编号 |
9055-57-6 |
| Comments |
The enzyme, found in bacteria and archaea, is activated by EC?2.8.1.7, cysteine desulfurase, which transfers a sulfur atom to an internal?L-cysteine residue, forming a cysteine persulfide. The activated enzyme then transfers the sulfur to a uridine in a tRNA chain in a reaction that requires ATP. The enzyme from the bacterium?Escherichia coli?forms 4-thiouridine only at position 8 of tRNA. The enzyme also participates in the biosynthesis of the thiazole moiety of thiamine, but different domains are involved in the two processes. |
| Cofactor |
|
| History |
|
| Reactions |
Atp + [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + uracil in tRNA + 2 reduced ferredoxin [iron-sulfur] cluster = Amp + diphosphate + 4-thiouracil in tRNA + [ThiI sulfur-carrier protein]-L-cysteine + 2 oxidized ferredoxin [iron-sulfur] cluster. |
