| 英文名 |
tRNAHis guanylyltransferase |
| Example Structure |
 |
| 别名 |
histidine tRNA guanylyltransferase, RBTH_06728, TGT, THG1, THG1L, Thg1p, TLP1, Tlp2 |
| EC Number |
2.7.7.79 |
| CAS编号 |
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| Comments |
In eukarya an additional guanosine residue is added post-transcriptionally to the 5′-end of tRNAHis?molecules. The addition occurs opposite a universally conserved adenosine73?and is thus the result of a non-templated 3′-5′ addition reaction. The additional guanosine residue is an important determinant for aminoacylation by EC?6.1.1.21, histidyl-tRNA ligase. The enzyme requires a divalent cation for activity [2]. ATP activation is not required when the substrate contains a 5′-triphosphate (ppp-tRNAHis) [3]. |
| Cofactor |
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| History |
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| Reactions |
p-tRNA(His) + Atp + gtp = pppG-P-tRNA(His) + amp + diphosphate. |
