| 英文名 |
tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase |
| Example Structure |
![Example Structure of tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase EC#: 2.1.1.290](/wp-content/uploads/enzyme-structure/2.1.1.290.jpg) |
| 别名 |
tRNA yW-synthesizing enzyme 4, tRNA-yW synthesizing enzyme-4, tRNA-yW synthesizing protein 4, TYW4, YOL141w |
| EC Number |
2.1.1.290 |
| CAS编号 |
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| Comments |
The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs. The modification is important for translational reading-frame maintenance. In some species that produce hydroxywybutosine the enzyme uses 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine37 in tRNAPhe as substrate. The enzyme also has the activity of EC 2.3.1.231, tRNAPhe 7-[(3S)-4-methoxy-(3-amino-3-carboxypropyl)wyosine37-O]-carbonyltransferase [2]. |
| Cofactor |
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| History |
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| Reactions |
S-adenosyl-L-methionine + 7-((3S)-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) = S-adenosyl-L-homocysteine + 7-((3S)-3-amino-3- (methoxycarbonyl)propyl)wyosine(37) in tRNA(Phe). |
