| 英文名 |
tryptophan 2-C-methyltransferase |
| Example Structure |
 |
| 别名 |
S-adenosylmethionine:tryptophan 2-methyltransferase, thiostrepton tryptophan methyltransferase, tryptophan 2-methyltransferase, TsrM, TsrT |
| EC Number |
2.1.1.106 |
| CAS编号 |
126626-83-3 |
| Comments |
The enzyme, characterized from the bacterium Streptomyces laurentii, is involved in thiostrepton biosynthesis. It is a radical SAM enzyme that contains a [4Fe-4S] center and a cobalamin cofactor. The enzyme first transfers the methyl group from SAM to the bound cobalamin, followed by transfer from methylcobalamin to L-tryptophan, resulting in retention of the original methyl group configuration. The second transfer is likely to involve a CH3 radical species formed from methylcobalamin by the concerted action of a partially ligated radical SAM [4Fe-4S]2+/1+ center. |
| Cofactor |
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| History |
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| Reactions |
S-adenosyl-L-methionine + L-tryptophan = S-adenosyl-L-homocysteine + L-2- methyltryptophan. |
